Personalized approach to patients with statin intolerance based on pharmacogenomics (function of OATP1B1 protein)
نویسندگان
چکیده
منابع مشابه
Pharmacogenomics in Pediatric Patients: Towards Personalized Medicine
It is well known that drug responses differ among patients with regard to dose requirements, efficacy, and adverse drug reactions (ADRs). The differences in drug responses are partially explained by genetic variation. This paper highlights some examples of areas in which the different responses (dose, efficacy, and ADRs) are studied in children, including cancer (cisplatin), thrombosis (vitamin...
متن کاملPharmacogenomics and Personalized Medicine
Pharmacogenetics is a newer branch of pharmacological sciences studying the relationship between genetic predisposition of an individual and his ability to metabolize a drug. It helps understand why some individuals respond to drugs and others do not, why some individuals require higher or lower doses to achieve an optimal therapeutic response, and tries to help the physician identify those pat...
متن کاملInsights Into Statin Intolerance
Stephen Kopecky, MD, FACC, FACP; Seth Baum, MD, FACC, FACPM, FAHA, FNLA; JoAnne M. Foody, MD, FACC, FAHA; Michael Koren, MD, FACC; James McKenney, PharmD, FNLA; Laurence Sperling, MD, FACC, FAHA, FACP; Nathan D. Wong, PhD, MPH, FACC, FAHA; Statin Intolerance Roundtable Participants Division of Cardiovascular Diseases (Kopecky), Mayo Clinic, Rochester, Minnesota; Women’s Preventive Cardiology Ce...
متن کاملPharmacogenomics: Translating functional genomics to personalized medicine
The emergence of human genome project brings hope of personalized medicine as patients with identical clinical symptoms may respond differently to the same drug therapy. Genetic polymorphisms in drug-metabolizing enzymes, transporters, receptors and other drug targets have been linked to differences in the efficacy and toxicity of many drugs between two individuals. Pharmacogenomics is the stud...
متن کاملMolecular mechanisms of statin intolerance
Statins reduce cardiovascular morbidity and mortality in primary and secondary prevention. Despite their efficacy, many persons are unable to tolerate statins due to adverse events such as hepatotoxicity and myalgia/myopathy. In the case of most patients, it seems that mild-to-moderate abnormalities in liver and muscle enzymes are not serious adverse effects and do not outweigh the benefits of ...
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ژورنال
عنوان ژورنال: Lijec?nic?ki vjesnik
سال: 2023
ISSN: ['0024-3477', '1849-2177']
DOI: https://doi.org/10.26800/lv-145-supl2-cr62